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“If the rate of cell division slows in old age,” Tomasetti says, “cells are probably accumulating fewer cancer-causing mutations at the end of life.” For example, Vogelstein says, it’s long been known that the incidence of most human cancers rises exponentially throughout a person’s life, but decelerates or even flattens out for several cancers toward the end of life - a phenomenon that wouldn’t make sense if cells were always steadily dividing and accumulating mutations at the same rate. The findings have numerous implications for better understanding cancer and aging, Tomasetti and Vogelstein say. In the duodenum, at the beginning of the small intestine, the rate slowed by 26% in the elderly, and in posterior ethmoid sinonasal tissue, found near the nose, the rate slowed by 83% in the elderly.
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Similarly, in samples of esophageal tissue, the division rate slowed by about 25% in the elderly compared with the younger patients. Their findings showed that cell division rates slowed by about 40% in colon tissue samples collected from patients in their 80s compared with those in their 20s. The researchers used dyes to stain various standard, tried-and-true molecular markers of cell division, such as the Ki67 antibody, to calculate cell multiplication rates, both “by eye” and with automated computer software. To test this hypothesis, the team analyzed cell replication rates in samples of various healthy tissues collected during biopsies and other medical procedures from more than 300 patients in their 20s and in their 80s. That analysis led Tomasetti and Vogelstein to suspect that cell division rates slow down markedly in old age, giving cells fewer chances to accumulate DNA mistakes. However, when Vogelstein, Tomasetti and colleagues reanalyzed old data in dozens of published papers as part of this study, they found that mutations accumulate more slowly in old age. Research in the last several decades assumed that such mutations accumulate over time at a steady rate, explains study leader Cristian Tomasetti, Ph.D., associate professor of oncology. Senior investigator Bert Vogelstein, M.D., the Clayton Professor of Oncology, co-director of the Ludwig Center at the Johns Hopkins Kimmel Cancer Center and a Howard Hughes Medical Institute investigator, pioneered the discovery that cancer is spurred by an accumulation of genetic mutations caused by mistakes cells make when copying DNA during cell division. 23 in the Proceedings of the National Academy of Sciences.
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*Note: the database is sortable/searchable on laptop or desktops, and on mobile if you install the Airtable app.The findings were published Sept. It is up to you to winnow, explore, focus, or curate as you wish.Īlso, don't forget to visit our Blog Page! You'll find weekly guest posts by authors of all kinds of recent books. Our goal is to help you aggregate a list of possibilities, based on your interests. It is comprehensive not 'qualitative.' While we're always working to improve, update, and maintain it, it may be the case that, particularly in some older titles, there may be content that you don't agree with. If you know of a book that belongs in the database that isn't listed, please email us! If the book was traditionally published, and significantly represents neurodiversity or a diagnosable mental health condition, we'd love to add it.ĭISCLAIMER: This database is a work in progress. Just a bit more info.Īnyhow, we hope the database helps you find that perfect book for that special reader. It's like when booksellers put a note on a book they've read and are recommending. If a book is marked with a Brainy, it means one of us has read and liked it. Please note you can search for books with LGBTQ and BIPOC main characters as well.Īlso note the column with our "Brainy" logo. There are lots of ways to sort, and one has to play around a bit. Use the "Group By" and "Filter" tabs to narrow what you're searching for. You can search by issue, publisher, author, title, whether the issue is in the main character, friend, parent or sibling - and more. Or picture books with ADHD - you can find that too.
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So, if you want to search for YA books with eating disorders, you can find that. Below, you will find our searchable database of more than 1000 traditionally published children’s books that touch on neurodiversity and mental health issues.